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CINP 2026｜Romina Mizrahi教授：精神分裂症研究的机遇与挑战

CCMTV 1754次浏览

2026-07-26

2026年6月26日-29日，第37届世界神经精神药理学大会（CINP2026）在英国格拉斯哥举行！这是时隔25年，世界神经精神药理学大会再度回归英国举办，本届大会以“携手促进脑健康（Advancing Brain Health Together）”为主题，汇聚全球领域顶尖专家共探前沿进展，是神经精神药理学领域的又一世界级盛会。

CCMTV精神频道作为大会官方唯一授权中国媒体，特别邀请到“Brain Health Research Award”获得者，麦吉尔大学Romina Mizrahi教授围绕精神分裂症基础研究的演进节奏、科研成果向临床实践转化的现实挑战，以及神经科学、免疫学与影像学交叉融合所带来的创新机遇，分享了极具前瞻性的学术思考。

△专家精彩视频

Winning the CINP Brain Health Research Award is high recognition of your years of research. Looking at the current landscape, how would you describe the overall pace and direction of basic research on schizophrenia?

本次斩获CINP脑健康研究奖，是学界对您多年科研工作的高度认可。站在当下，您如何看待精神分裂症基础研究整体的发展节奏与整体走向？

Romina Mizrahi 教授

I believe we are in a remarkable era for precision psychiatry, given the ongoing search for biomarkers, the identification of novel therapeutic targets, and the potential development of new medications that will specifically address distinct brain changes, rather than targeting clinical symptoms or disease categories defined solely by psychiatric manuals. In this context, I think that investigating potential biomarkers and examining how environmental factors influence brain function will fundamentally transform our approach to treating mental health disorders, as well as substance use disorders, in the future.

我认为，当前正是精准精神病学发展的关键时期，这得益于生物标志物的持续探索、新型治疗靶点的识别，以及可能开发出针对特定脑部变化的新药。这些新药将不再仅针对精神疾病诊断手册中定义的临床症状或疾病分类。在这一背景下，我相信，研究潜在生物标志物并探讨环境因素如何影响脑功能，将从根本上改变我们未来治疗心理健康障碍及物质使用障碍的方法。

It usually takes a long time for basic research findings to serve clinical practice. Based on your experience, what common difficulties exist in the clinical translation of schizophrenia research?

基础研究成果想要真正服务临床，往往需要经历漫长的转化过程。结合您的实践经验，您认为精神分裂症相关研究在临床转化路上普遍存在哪些共性难点？

Romina Mizrahi 教授

There are numerous contributing factors to this phenomenon. One, of course, is economics, as well as the years required to translate a research finding into clinical practice. However, again, because of the rapid pace of social media and artificial intelligence, I believe that these factors, together with forthcoming regulatory changes, will accelerate the translation of basic research into clinical care far more quickly than has been previously possible. Of course, this will also require changes in regulatory frameworks, which I think will themselves be influenced by AI. Overall, I believe we are at a promising moment in schizophrenia research.

造成这一现状的诱因有很多。首要因素自然与经济层面相关，同时将研究成果转化为临床应用本身也需要漫长周期。但得益于社交媒体与人工智能的高速发展，再加上后续监管政策的持续优化，我认为基础研究向临床应用转化、临床诊疗整体发展的速度，都会远超以往。相应地，监管体系也必须同步调整，而人工智能也将推动监管体系的革新。综合来看，精神分裂症研究当下正迎来前景向好的发展阶段。

Interdisciplinary integration has become a major trend, with neuroscience, immunology and imaging all contributing to schizophrenia research. What unique opportunities do you think cross-disciplinary cooperation will bring to this field?

如今多学科交叉融合已经成为主流趋势，神经科学、免疫学、影像学等领域都在参与精神分裂症的探索。您认为跨学科合作能为该领域带来哪些独有的发展机遇？

Romina Mizrahi 教授

I think this is amazing. It is an extraordinary time for us, because we will be able to integrate all levels of research, from preclinical to clinical, and with the support of artificial intelligence as well as human critical reasoning. We will be able to treat various mental health conditions, including substance use disorders, in ways that were not possible before. In this regard, I would like to thank the CINP again for this wonderful award, and also thank CCMTV for inviting me to give this presentation. I look forward to seeing all of you in Glasgow.

我认为这非常令人振奋。对我们来说，这是一个非凡的时代，因为我们能够整合从临床前到临床各个层面的研究，并借助人工智能以及人类的批判性思维。我们将能够以过去无法实现的方式，治疗包括物质使用障碍在内的多种精神健康疾病。在此，我再次感谢CINP授予我这个殊荣，也感谢CCMTV邀请我进行此次演讲。我期待在格拉斯哥与大家相见。

专家介绍

Expert presentation

Romina Mizrahi

McGill University

Director of MRCC, Professor

Dr Mizrahi obtained her M.D. degree from the University of Buenos Aires in 1998 and her Ph.D. in 2007 from the University of Toronto. Dr. Mizrahi seeks to understand early molecular changes in the brain of youth with psychosis and addictions with the hope to identify novel targets for prevention, intervention and treatment.

【免责声明】本文仅供医学学术交流与专业知识分享，不构成任何临床诊疗依据，亦不作为药品、医疗器械的商业推广或诊疗指导。文中内容与本文所提及的相关企业无任何直接或间接利益关联；所有观点均基于专家个人临床实践及公开学术研究，立场客观中立，绝无商业利益倾向。CCMTV平台仅作为学术传播交流载体，不对内容的临床应用承担任何医疗及法律责任。读者在作出任何临床决策前，请严格遵循国家诊疗规范及法律法规。

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