That's a great question. First of all, thank you so much for having me. In terms of important qualities and abilities, especially in today's research environment, I think it's crucial for young researchers to be truly curious. They shouldn't be afraid to read outside their primary area of interest and develop a broad understanding. The ability to collaborate is also essential, and they should not be afraid to ask difficult questions. We all start somewhere, and building up knowledge in this field is a gradual process.

I typically guide my trainees by paying close attention to their interests. I try to find projects that they are truly passionate about because I recognize that research can be challenging and sometimes daunting. It's important that they feel attached to and enthusiastic about their projects. Ultimately, we conduct this type of research with the goal of helping patients with neuropsychiatric disorders. I believe this curiosity and drive to improve the human condition are very important.

在我看来，年轻研究者在神经精神药理学领域最需要具备的关键素质和能力包括：一是真正要有极大的勇气，不要害怕涉足自己可能原本不太感兴趣的领域；二是具备合作的能力，并且不要害怕提出难题性的问题。毕竟，我们每个人都是从某个起点开始的，而在这个研究领域，人们可以通过不断积累知识来逐步成长。

在指导学员时，我通常会认真关注他们的兴趣，引导他们进行研究，并努力找到真正能让他们感兴趣的研究项目。因为研究是一项很棒的活动，但有时也会充满挑战，让人望而却步。在我的职业生涯中，我发现让人们真正对项目产生浓厚兴趣并充满热情是非常重要的。此外，我们进行这种研究的最终目的是为了帮助患有神经精神疾病的患者，这是一个非常重要的使命。而那种对改善人类状况的好奇心和努力去实现这一目标的驱动力，也是非常重要的。

I don't know if I can say there is a specific type of research that is my favorite these days, but it is certainly very important to conduct rigorous research. This means pre-registering hypotheses and analyses and tackling potentially impactful topics. There is a place in science for incremental steps; small projects can help us get closer to the truth or uncover specific associations. At times, there are studies that can really shape the field and bring about incremental advances.

With my mentees and colleagues, I try to foster a culture of humility and curiosity. We need to be open-minded and willing to adjust our theories based on findings, not the other way around. Sometimes our theories are not confirmed, and it's important to understand why, as this can open up new directions. As an editor for several journals, I believe these qualities are key to producing high-quality and innovative research.

在当今的科研环境中，我认为严谨的研究态度是至关重要的。这不仅意味着要预先设定清晰的假设并进行周密的分析，还要求我们敢于挑战那些可能对整个领域产生深远影响的课题。当然，科学研究的进程往往是渐进式的，每一步都可能让我们更接近真相。有时候，一些看似微小的进展，实际上可能为未来的重大突破奠定基础。

作为多个期刊的编辑，我深知保持谦逊和好奇心的重要性。科学探索是一场不断试错的旅程，我们的理论并非总是能够得到验证。当结果与预期不符时，我们需要勇敢地重新审视自己的假设，而不是固执己见。这种开放的心态不仅能帮助我们避免陷入思维的僵局，还可能为我们指引全新的研究方向。因此，我常常鼓励我的团队和同事们保持这种灵活的态度，以应对不断变化的科学挑战。这种对研究质量的严格把控以及对创新的不懈追求，正是我所倡导的科研精神。

There are so many exciting directions in depression research, and that's part of what makes this field so fascinating—there are endless questions to explore. But one critical area that I believe is often overlooked is the phenotype of depression. Depression is incredibly heterogeneous, not just in clinical presentation but also likely in terms of etiology and pathophysiology. Many studies simply compare individuals with major depressive disorder to healthy controls, and while we can derive some important information from this approach, it may not significantly advance our understanding. Instead, I think it's essential to pay attention to different symptom presentations and phenotypes. This granularity is crucial for making tangible progress in this area.

In psychiatry, particularly with depression, we still rely on a trial-and-error approach. Patients might try specific medications, psychotherapy, or neurostimulation, but this method is inefficient and often ineffective for many. Currently, only about 50% to 55% of patients respond well to specific antidepressants, psychotherapy, or neurostimulation. This highlights the urgent need for personalized treatments.

The field of personalized treatments is where I see great potential for progress. By focusing on individual symptoms, genetic backgrounds, and biomarkers, we can hopefully develop more precise and effective treatment strategies. This is not just a scientific imperative but a moral one, as we aim to improve patients' symptoms and quality of life more rapidly.

抑郁症研究领域存在一个亟待解决的问题：我们往往忽视了抑郁症的异质性。抑郁症不仅在临床表现上呈现多样性，其病因和病理机制也极为复杂。目前，许多研究仅仅将抑郁症患者与健康对照组进行比较，虽然能够提供一些有价值的信息，但这种研究方式难以推动我们对抑郁症的深入理解。

我认为，未来的研究需要更加关注抑郁症的不同表型，即不同的症状表现和疾病特征。只有通过细致地分类和研究这些表型，我们才能真正揭示抑郁症的复杂本质，并为患者提供更加精准的治疗方案。目前，抑郁症的治疗仍然依赖于试错法，患者往往需要尝试多种药物或治疗方法才能找到最适合自己的方案。这种现状不仅增加了患者的痛苦，也凸显了个性化治疗的迫切需求。

个性化治疗无疑是未来抑郁症研究的重要方向。通过深入研究每个患者的独特症状、遗传背景和生物标志物，我们有望开发出更加精准、高效的治疗方法。虽然目前这一领域的进展还相对缓慢，但随着技术的进步和研究的深入，我相信我们终将实现这一目标。毕竟，我们的最终使命是改善患者的症状，提高他们的生活质量。这不仅是一个科学问题，更是一个关乎人类福祉的使命。