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年度补全集｜风湿免疫领域的“其他研究”你看了吗？ (2024-2025)

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2025-08-12

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Rheumatol

Autoimmun

导读

Rheumatology & Autoimmunity

风湿免疫病谱持续拓展，临床实践与研究关注的焦点也愈发多元。本期合集聚焦2024–2025年风湿免疫领域中的“其他研究”，内容涵盖疫苗相关反应、罕见病管理、中西医结合治疗策略、工具量表验证及复杂病例识别等多个方向。

从纤维性骨化病到免疫性血小板减少，从糖尿病相关并发症到肉芽肿性疾病，每一篇文章都代表着临床难点与科研空白的填补与突破。一文读懂疾病的最新动向，值得关注，也值得收藏。

【Review】Coronavirus disease 2019 vaccination in patients with rheumatic diseases: A bibliometric‐based analysis of trends

Xiufang Kong, Wei Wang

本研究旨在对COVID-19疫苗接种在风湿病患者中的研究进行全面的文献计量学分析，并指出未来研究的可能方向。共纳入文献615篇，来自79个国家/地区的1693个机构、5068位作者，刊载于194种期刊，其中文章505篇，综述110篇。当前的文献分析结果显示，疫苗安全性、免疫原性和抗体应答是风湿病患者接种COVID-19疫苗领域的研究热点和前沿。未来风湿病患者接种COVID-19疫苗的研究可重点关注抗体应答、验证和安全性。

How to cite: Kong X, Wang W. Coronavirus disease 2019 vaccination in patients with rheumatic diseases: a bibliometric-based analysis of trends. Rheumatol Autoimmun 2024; 4: 81-89. doi:10.1002/rai2.12132

Article link:

https://onlinelibrary.wiley.com/doi/10.1002/rai2.12132

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【Review】New sights into new‐onset and relapsed minimal change disease post COVID‐19 vaccination: A systemic review of the clinical characteristics and underlying pathogenesis

Jiarong Liu, Gaosi Xu

本文对2019冠状病毒病(COVID-19)疫苗接种后肾活检诊断的微小病变肾病(MCD)患者进行了分析，认为新发MCD在疫苗接种后的实验室检查结果和临床表现方面均较复发MCD更为严重。总体而言，糖皮质激素和免疫抑制治疗相结合是治疗该病的有效方法。

How to cite: Liu J, Xu G. New sights into new-onset and relapsed minimal change disease post COVID-19 vaccination: a systemic review of the clinical characteristics and underlying pathogenesis. Rheumatol Autoimmun 2024; 4: 145-155. doi: 10.1002/rai2.12126

Article link:

https://onlinelibrary.wiley.com/doi/10.1002/rai2.12126

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【Review】Hetrombopag: A promising thrombopoietin receptor agonist for the treatment of primary and secondary immune thrombocytopenia

Jiaqi Hu, Zhida Fu, Xia Xu, Zhengyi Jin, Xinyu Qian, Weiyu Tao, Taiyan Ma, Dongbao Zhao, Jie Gao

目前研究表明血小板生成素受体激动剂作为特发性免疫性血小板减少症的二线治疗方案，具有良好的疗效、耐受性和安全性。目前尚无海曲泊帕（hetrombopag）在继发性血小板减少症中超适应证使用的报道；但众多研究表明艾曲泊帕（eltrombopag）对难治性血小板减少症患者有效，可维持血小板计数稳定。海曲泊帕与艾曲泊帕结构相似，且海曲泊帕疗效更佳、毒性更低。因此，海曲泊帕用于原发及继发性免疫性血小板减少症的治疗前景广阔，值得进一步研究。

How to cite: Hu J, Fu Z, Xu X, et al. Hetrombopag: a promising thrombopoietin receptor agonist for the treatment of primary and secondary immune thrombocytopenia. Rheumatol Autoimmun 2025; 5: 101-115. doi:10.1002/rai2.70000

Article link:

https://onlinelibrary.wiley.com/doi/10.1002/rai2.70000

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【Systematic Review】Future of fibrodysplasia ossificans progressiva management: A systematic review of investigational therapies

Muhammad Ikrama, Muhammad Usama, Shifa Israr, Maryam Humayon, Muhammad Umair Javaid, Shafqat Abbas, Muhammad Aliyan Haider

进行性骨化性纤维发育不良是一种由ACVR1基因突变引起的罕见遗传病，可导致软组织骨化。最近的研究中，食品和药物管理局批准了帕罗伐汀，给疾病的治疗带来了希望。托法替尼和伊马替尼等疗法显示出潜力，但更大规模的对照试验对于探索基因疗法和联合疗法至关重要。

How to cite: Ikrama M, Usama M, Israr S, et al. Future of fibrodysplasia ossificans progressiva management: a systematic review of investigational therapies. Rheumatol Autoimmun 2025; 5: 28-36. doi:10.1002/rai2.12168

Article link:

https://onlinelibrary.wiley.com/doi/10.1002/rai2.12168

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【Meta Analysis】Efficacy and safety of traditional Chinese medicine and SGLT2i, GLP-1RA, and ACEI/ARB in the management of diabetic kidney disease: A systematic review and network meta-analysis

Jiarong Liu, Jixiong Xu

本文采用网状meta分析确定糖尿病肾病患者最推荐的治疗方案。该研究最终纳入了87项随机对照试验，包括16种不同的治疗方法和10,485例患者。血管紧张素转换酶抑制剂联合中药治疗可能是降低糖尿病肾病患者24小时尿总蛋白、血尿素氮、血清肌酐的最佳选择，而血管紧张素受体阻滞剂联合胰高血糖素样肽-1受体激动剂降低糖化血红蛋白的效果最佳。

How to cite: Liu J, Xu J. Efficacy and safety of traditional Chinese medicine and SGLT2i, GLP-1RA, and ACEI/ARB in the management of diabetic kidney disease: a systematic review and network meta-analysis. Rheumatol Autoimmun 2025; 5: 37-49. doi:10.1002/rai2.12172

Article link:

https://onlinelibrary.wiley.com/doi/10.1002/rai2.12172

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【Original Article】Validity and reliability of Sarcopenia Quality of Life® Indonesia questionnaire in sarcopenic patients

Anna Ariane, Purwita W. Laksmi, Siti Setiati, Rudy Hidayat, Suryo Anggoro Kusumo-Wibowo, Sumariyono, Fadhli Mahri, Caroline Tanadi, Charlotte Beaudart

Sarcopenia Quality of Life®（SarQol®)是目前唯一针对肌少症的生活质量评估工具。由于肌少症显著损害生活质量，这一特异性工具可以更好地评估患者的病情和疾病进展。本文是继中国之后在亚洲开展的第二项SarQol®验证研究。结果证明SarQol®是测量亚洲人群肌少症生活质量的有效工具。本研究还使用生物电阻抗分析法测量肌少症诊断的肌肉质量成分，确保了诊断的准确性。

How to cite: Ariane A, Laksmi PW, Setiati S, et al. Validity and reliability of Sarcopenia Quality of Life® Indonesia questionnaire in sarcopenic patients. Rheumatol Autoimmun 2024; 4: 47-56. doi: 10.1002/rai2.12118

Article link:

https://onlinelibrary.wiley.com/doi/10.1002/rai2.12118

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【Original Article】Investigation of COVID-19 infection in patients with polymyalgia rheumatica during the predominance of the omicron variant

Xinlei Ma, Lanlan Xiao, Jinzhi Wu, Guanhua Xu, Jin Lin, Weiqian Chen

风湿性多肌痛(PMR)是一种影响老年人的炎症性疾病，本研究探讨了在奥密克戎变异株流行期间，被诊断为PMR的患者与2019冠状病毒病(COVID-19)感染相关的风险和预后。PMR患者对COVID-19易感性的增加可能受其原有疾病活动度的影响。

How to cite: Ma X, Xiao L, Wu J, Xu G, Lin J, Chen W. Investigation of COVID-19 infection in patients with polymyalgia rheumatica during the predominance of the omicron variant. Rheumatol Autoimmun 2024; 4: 174-179. doi: 10.1002/rai2.12129

Article link:

https://onlinelibrary.wiley.com/doi/10.1002/rai2.12129

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【Letter to the Editor】Unusual presentation of multiorgan extrapulmonary sarcoidosis

Ana Lilia Peralta Amaro, Tania Stefanía Cabrera Castillo, María de los Ángeles Macias Clavijo, Fernando Méndez Gallegos, Abihai Lucas Hernández

本文介绍了一个独特的结节病病例，表现为血小板减少症和可能的神经结节病，患者没有肺部症状。识别这些非典型症状至关重要，有助于考虑潜在的鉴别诊断。

How to cite: Peralta Amaro AL, Cabrera Castillo TS, Macias Clavijo MdlÁ, Méndez Gallegos F, Lucas Hernández A. Unusual presentation of multiorgan extrapulmonary sarcoidosis. Rheumatol Autoimmun 2024; 4: 62-64. doi: 10.1002/rai2.12107

Article link:

https://onlinelibrary.wiley.com/doi/10.1002/rai2.12107

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【Letter to the Editor】Prevalence of diabetic cheiroarthropathy and its association with macrovascular complications: A cross-sectional study

Athul Paul, Kothai Gnanamoorthy, Gisha Sivan, Janardanan S. Kumar

糖尿病性手关节病 (DCA) 患病率在28.5%到29.0%之间，患病率随着年龄的增长而增加，这与之前将 DCA 与衰老联系起来的发现一致。分析显示糖尿病病程与 DCA 之间存在显著关联，表明糖尿病病程越长，风险越高。那些在青春期前发病糖尿病的人表现出更严重的关节活动受限，这归因于生长突增期间高血糖诱导的胶原蛋白沉积。长期高血糖导致非酶胶原糖基化，导致耐药性胶原积聚和蛋白质捕获，加剧细胞外基质发育。

How to cite: Paul A, Gnanamoorthy K, Sivan G, Kumar JS. Prevalence of diabetic cheiroarthropathy and its association with macrovascular complications: A cross sectional study. Rheumatol Autoimmun 2024; 4: 189-191. doi: 10.1002/rai2.12138

Article link:

https://onlinelibrary.wiley.com/doi/10.1002/rai2.12173

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【Letter to the Editor】Blau syndrome with incidental multiple enchondromatosis

Xiaozhen Zhao, Junmei Zhang, Weiying Kuang, Jianghong Deng, Xiaohua Tan, Chao Li, Shipeng Li, Caifeng Li

本文报告了一个罕见的Blau综合征(BS)病例，表现为与非干酪性肉芽肿病变无关的溶骨性骨病变。这一发现提示BS的骨损害不仅是干酪样的，还包括骨软骨瘤。图中为患者右手x线及磁共振成像、基因测序及家系分析。

How to cite: Zhao X, Zhang J, Kuang W, et al. Blau syndrome with Incidental Multiple Enchondromatosis. Rheumatol Autoimmun 2024; 4: 183-185. doi: 10.1002/rai2.12121

Article link:

https://onlinelibrary.wiley.com/doi/10.1002/rai2.12121

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【Letter to the Editor】Misleading ulcers: A rare case of lymphomatoid papulosis initially diagnosed as acquired reactive perforating collagenosis

Zhongyu Chen, Qiutian Lei, Binbin Yang, Danqi Deng

本病例报道了一名罕见的以广泛溃疡为主要表现的21岁女性淋巴瘤样丘疹病（LyP）患者，初期误诊为皮肤脓肿、坏疽性脓皮病及获得性反应性穿通性胶原病，常规免疫抑制治疗无效。病理提示异型淋巴细胞浸润，免疫组化示CD30阳性，确诊为LyP A型。患者拒绝甲氨蝶呤治疗，经局部治疗后皮损缓解，2年随访未复发。本例提示LyP临床表现多样，广泛溃疡亦可为首发表现，鉴别诊断中应考虑该病，避免误治；同时强调长期随访的重要性，以警惕其与其他淋巴增殖性疾病的关联。

How to cite: Chen Z, Lei Q, Yang B, Deng D. Misleading ulcers: a rare case of lymphomatoid papulosis initially diagnosed as acquired reactive perforating collagenosis. Rheumatol Autoimmun 2025; 5: 155-156. doi:10.1002/rai2.12166

Article link:

https://onlinelibrary.wiley.com/doi/10.1002/rai2.12166

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【Clinical Image】Miliary mottling in systemic arthritis: A diagnostic and therapeutic dilemma

Sabarinath Mahadevan, Balakrishnan Navaneethakrishnan, Mahabaleshwar Mamadapur, Ponniah Subramanian ArulRajamurugan

本文报道1例全身型幼年特发性关节炎 (SOJIA)，起病于婴儿期，病程早期出现罕见的肺部表现。SOJIA患儿粟粒状斑驳样间质性肺疾病少见，可能给临床医师的诊断和治疗带来挑战。上图为患者皮肤及胸部高分辨率CT表现。（A、B）一过性黄斑皮疹。(C)胸部高分辨率CT表现为随机分布的粟粒性结节。(D)治疗后6个月复查。

How to cite: Mahadevan S, Navaneethakrishnan B, Mamadapur M, ArulRajamurugan PS. Miliary mottling in systemic arthritis: a diagnostic and therapeutic dilemma. Rheumatol Autoimmun 2025; 5: 77-79. doi:10.1002/rai2.12156

Article link:

https://onlinelibrary.wiley.com/doi/10.1002/rai2.12156

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校正、内容、排版 | RAI编辑部

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